Metabolomics Service Offerings
From Discovery to the Clinic
Metabolomics is a revolutionary technology for obtaining a comprehensive picture of the metabolome and mapping metabolites to their key biochemical pathways. It helps answer a wide variety of research questions and gives crucial insight into the function of genes, the basis of disease, and how treatments work. It can also identify associated biomarkers, making it an attractive tool for investigators across multiple applications.
Many laboratories have metabolite profiling or analytical chemistry capabilities, but none have the technology and workflow that allow Metabolon to produce the most comprehensive, high-quality and accurate metabolomics data available. Our unique bioinformatics infrastructure and data interpretation experience transform that data into knowledge that you can immediately put into action.
Metabolon offers a range of metabolomics service offerings that support and advance research at every stage. Whether you want to survey the entire metabolome, only complex lipids, or just a few key pathways or metabolites, our team of experts will work with you to clearly define your goals and develop a customized plan to meet them.
Our Metabolomics services are powered by DiscoveryHD4™, the industry’s most comprehensive global metabolomics platform. This automated platform quickly and accurately identifies and quantitates over 1,000 metabolites across all major classes of metabolites, with less than 5% process variability in almost any sample type. Covered classes include Amino Acids, Carbohydrates, Lipids, Nucleotides, Microbiota metabolism, Energy, Cofactors & Vitamins, Xenobiotics, and Novel Metabolites.
Through thousands of studies, Metabolon has developed the expertise, infrastructure and bioinformatics solutions to quickly and accurately extract the key findings from metabolomics data.
Lipidomics is a more focused form of metabolomics that surveys complex lipids. Our Complex Lipid Panel is the only lipidomics method able to provide absolute quantitation, molecular species concentration and complete fatty acid composition of each covered lipid class. This unique method covers more than 1,100 molecular species across 16 lipid classes, including principle phospholipid, sphingolipid and neutral lipid classes.
Targeted Metabolite Assays
Targeted Metabolite Assays and panels zoom in on a specific metabolite or metabolic pathway, offering in-depth insight into specific metabolic reactions. Targeted assays can be used to track biomarkers and improve biological understanding in both clinical and preclinical research.
You can select from an ever-expanding, diverse menu of 150+ pre-developed assays (qualifed and/or validated) for research or clinical trial use, including fatty acids, bile acids and amino acids, such as:
- Fatty Acid Metabolism Panel: measures the major fatty acids of importance to human and animal metabolism, including saturated, mono-unsaturated omega-3, omega-6, trans and plasmalogen-derived fatty acids.
- Short-Chain Fatty Acid Panel: measures short-chain fatty acids in a variety of biological matrices. Quantitative measurements of SCFA can help elucidate the importance of the gut microbiome on human health.
- Bile Acid Panel: measures all major primary and secondary bile acids, as well as their glycine and taurine derivatives.
- Cholesterol Metabolism Panel: measures cholesterol, as well as intermediates in cholesterol synthesis and oxidation, phytosterols, and metabolic products of cholesterol to provide a comprehensive snapshot of sterol synthesis, absorption and excretion.
- Stratum Corneum Panel: measures more than 350 individual lipid metabolites found in stratum corneum, including free fatty acids, cholesterol sulfate, ceramides, dihydroceramides and phytoceramides.
- Sebum Lipid Panel: measures over 900 individual lipid species from multiple lipid classes, including wax esters and squalene. The fatty acids comprising the complex lipid classes are largely unique to skin metabolism and include odd and branched-chain fatty acids and a high concentration of the unusual sapienic acid (16:1n10) and its metabolites.
- accuGFR™: provides an estimate of the Glomerular Filtration Rate (GFR) that is more precise than current standard-of-care eGFR methods based on creatinine of cystatin C (MDRD or CKD-EPI), and it is independent of creatinine or cystatin C.
- 7 alpha-hydroxy-4-cholesten-3-one (C4): measurement in peripheral blood provides an assessment of the rate of bile acid synthesis in the liver.
- Metal Ion Panel: provides precise measurements of biologically important macro- and micro-nutrient metals, such as zinc, chromium, magnesium and iron, in plasma, serum or urine.
- Custom Assays: provides precise measurement of metabolites in a wide variety of matrices. Metabolites can be valuable biomarkers because they are sensitive to specific enzyme inhibitors and signaling pathways and are associated with many diseases.