About the Test


Quantose™ IR is a laboratory-developed test (LDT) based on insulin and three non-glycemic biomarkers. It is the first and only test clinically developed and validated to measure insulin resistance. It is a simple, easy-to-use test requiring only a single, fasted blood draw. 


  • What does the Quantose™ IR test measure?

    • Designed to closely approximate scores obtained from the hyperinsulinemic euglycemic clamp – the gold standard for measuring Insulin Resistance
    • Quantose™IR Score is generated using a proprietary algorithm which combinesquantitative measures of α-hydroxybutyrate (AHB), oleic acid, linoleoyl-glycerophospocholine (LGPC) and insulin

    • α-Hydroxybutyrate (AHB) – an organic acid that is a marker of fatty acid oxidation and antioxidant glutathione synthesis (oxidative stress)

    • Linoleoyl-glycerophosphocholine (LGPC) – a lipid that is a marker of fatty acid synthesis in the liver and inflammation

    • Oleic acid – a free fatty acid that is a marker of lipolysis and total plasma fatty acids 
  • How are the results reported, and what do they mean?

    • A report is delivered directly to the healthcare provider by the laboratory performing the test.  Results are reported as a Quantose™ IR Score – a value between 1 and 120
    • Quantose™ IR Scores at or above a predefined cutoff are indicative of Insulin Resistance 
  • What is the difference between Quantose™ IR and other Insulin Resistance tests?

    • Quantose™ IR is the laboratory developed test that has been clinically developed and validated using the hyperinsulinemic euglycemic clamp, (aka “clamp”), the gold standard for insulin sensitivity measurement.  Quantose™IR brings the accuracy of the Insulin Resistance assessment into clinical practice

    • HOMA-IR provides a simple method for Insulin Resistance measurement.  However, this test is less accurate than Quantose™IR in identifying Insulin Resistance as measured by the clamp1. It is not standardized, and it only primarily measures liver Insulin Resistance.  Importantly, results from this test may vary up to 30%.

    • Fasting insulin does not have a defined Insulin Resistance cutoff and results vary widely between laboratories.2

    • Hemoglobin A1C and fasting plasma glucose were not designed to measure Insulin Resistance.  They measure a patient’s glycemic status. 


    The Quantose™ IR test combines the accuracy of the clamp with the convenience of HOMA-IR in a standardized tool for use in clinical practice. Quantose™ IR is capable of identifying the early stages of the transition towards Type 2 Diabetes and cardiovascular disease, years before changes in hemoglobin A1C and fasting plasma glucose are visible.

    1Cobb et al J.Diabetes Science and Technology 2013

    2Data on file at Metabolon